Table 2 . Therapeutic responses after intramuscular artemether or intramuscular sulfadoxine-pyrimethamine in children with P. falciparum malaria (There was no significant differences in the mean of the age, weight, initial temperature and fever between the two groups employed. Cure number appearance of parasitemia within 14 days. R1 parasitemia disappears but re-appears within 7-14 days, R11 decrease of parasitemia but no complete clearance from peripheral blood, R111 no pronounced decrease or increase in parasitemia 48 h after treatment).
 
  Artemether Sulfadoxine-pyrimethamine
Fever clearance time ( h)

Range

Mean ( SD)

 6-24

12.6 (6.6)

 6-60a (n = 5)

33.6 (19.2)**
Parasites clearance times

(h)

Time to 50 % clearance

Range

Mean (SD)

Time to 90 % clearance

Range

Mean (SD)

Time to 100 % clearance

Range

Mean (SD)
 
 

6-24

12.6 (6.6)

9-34

18.2 (6.6)

30-72

41.4 (11.1)
 
 

10-26.5

19.8 (7.7)***

24-30

26.9 (7.4)+

36-168 (n = 4)

93 (55.7)++
Response ( no of patients)

Cure 

R1

R11

R11

Cure Rate at day 14

 10

0

0

0

100%

 4

1

1

1

45%

(Sowunmi and Oduola 1998). a Fever did not clear two patients

** p < 0.01, *** p < 0.05, +p < 0.03, ++p < 0.01
 


 


Back